Under the background of global warming, studying the characteristics of dry-wet climate changes in the Shiyang Rive Basin and their influence on vegetation coverage has significant importance for the ecological environment construction of the basin. Based on the precipitation temperature homogenization index (S) in the Shiyang River Basin from 1971 to 2020, the spatial-temporal changes of the dry-wet climate in the basin were analyzed from the aspects of drought station frequency ratio, drought frequency, and more. Combined with the Normalized Differential Vegetation Index (NDVI) remote sensing data, the influence of dry-wet change on NDVI was analyzed. The results showed that the inter-annual and seasonal S indices showed an increasing trend in the Shiyang River Basin over the past 50 years, with the most pronounced increase in summer. The drought degree and drought occurrence area have shown a decreasing trend in the basin. The intensity of drought in the midstream and downstream were more severe compared to the upstream, with higher drought frequencies in the downstream. The annual NDVI increased with the alleviation of drought, the increase of precipitation and decrease of temperature. The precipitation in the early and middle period of growth, as well as the temperature in the middle period had a great influence on the annual NDVI. In February, May and July, the NDVI had a lag effect in response to drought.